Description

Atrial Natriuretic Peptide (126-149) (Rat) is a specific, bioactive fragment of the rat ANP hormone, a critical regulator of blood pressure and electrolyte balance. This high-purity peptide is essential for cardiovascular research, providing a precise tool for studying natriuretic peptide receptor interactions and signaling pathways. It is primarily used by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on hypertension, heart failure, and renal function studies.

Application

• Cardiovascular Research: Used as a reference standard and active agent in studies investigating blood pressure regulation, vasodilation, and natriuresis.
• Receptor Binding Assays: Essential for competitive binding studies to characterize and quantify ANP receptor subtypes (NPR-A, NPR-C).
• In Vitro & Ex Vivo Studies: Applied in cell-based assays and isolated tissue/organ preparations to study cyclic GMP signaling and cellular responses.
• Biomarker Development: Serves as a calibrator or immunogen in the development of immunoassays (ELISA, RIA) for detecting ANP-related peptides.
• Pharmacological Screening: Utilized in high-throughput screening platforms to identify novel modulators of the natriuretic peptide system for drug discovery.
• Educational & Diagnostic Kit Manufacturing: Supplied as a key component in research kits and for educational purposes in advanced physiology and pharmacology.

Basic Information

Product Name	Atrial Natriuretic Peptide (126-149) (Rat)
CAS No.	91421-87-3
Molecular Formula	C119H190N36O39S2
Molecular Weight	2745.1 g/mol
Synonyms	ANP (126-149), Rat; Atriopeptin (126-149); Cardionatrin (126-149); rANP(126-149); Atrial Natriuretic Factor Fragment (126-149); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Every batch of Atrial Natriuretic Peptide (126-149) (Rat) is manufactured and tested under strict quality systems. Our products undergo rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This hygroscopic and easily oxidized material should be handled under an inert atmosphere when possible and allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.