Description

(R)-Lorazepam is the single enantiomer of the well-known benzodiazepine derivative, distinguished by its specific stereochemistry at the chiral center. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and reference standards. It is primarily sought after by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in advanced drug development, chiral separation studies, and metabolic research.

Application

• Chiral Pharmaceutical Intermediate: Key building block for the synthesis of enantiomerically pure benzodiazepine-based therapeutics.
• Reference Standard: Used as a high-purity standard in analytical methods development and validation for HPLC, GC, and chiral chromatography.
• Metabolic and Pharmacological Research: Essential for studying the stereoselective metabolism, pharmacokinetics, and receptor binding affinity of lorazepam enantiomers.
• Process Development: Serves as a critical material in developing and scaling up asymmetric synthesis routes.
• Impurity Profiling: Used to identify and quantify the (R)-enantiomer as a potential impurity in batches of the racemic mixture or the (S)-enantiomer.

Basic Information

Product Name	(R)-Lorazepam
CAS No.	91402-80-1
Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.16 g/mol
Synonyms	(R)-Lorazepam; (R)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; (-)-Lorazepam; Lorazepam R-enantiomer; UNII-5O8U8D8T5U; (R)-(-)-Lorazepam; (3R)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our (R)-Lorazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, chiral purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.