Description

D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride is a synthetic peptide derivative, specifically a modified fragment of Substance P, designed for enhanced stability and targeted biological activity. This compound is of significant value in advanced research and development due to its role as a potent and selective neurokinin-1 (NK1) receptor antagonist. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and inflammatory pathway studies.

Application

• Neuroscience Research: Used as a critical tool compound for studying the role of Substance P and NK1 receptors in pain signaling, neuroinflammation, and central nervous system disorders.
• Pharmacological Development: Serves as a reference standard and lead structure in the development of novel analgesic and anti-inflammatory therapeutics targeting neurokinin pathways.
• Biochemical Assays: Employed in competitive binding assays and functional studies to characterize receptor affinity and antagonist potency in vitro.
• Academic & Preclinical Studies: Facilitates fundamental research into emesis, depression, and migraine, where the NK1 receptor is a known therapeutic target.

Basic Information

Product Name	D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride
CAS No.	91224-37-2
Molecular Formula	C78H108N22O13 • xHCl
Molecular Weight	~1586.8 g/mol (free base)
Synonyms	Sendide; [D-Arg1, D-Trp7,9, Leu11]-Substance P; Neurokinin-1 Receptor Antagonist (Sendide); Substance P (6-11) Antagonist; H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 hydrochloride; Sendide acetate; NK1R Antagonist Peptide
EINECS	Contact for details

Quality Control

Our D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride is manufactured under strict quality systems suitable for research and development. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure consistent quality and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Assay (Peptide Content)	≥80%
Single Impurity (HPLC)	≤1.0%
Water Content (KF)	≤8.0%
Acetate Content (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.