Description

Pglu-Phe-Gly-Oh CAS NO 90986-81-5 is a synthetic tripeptide derivative, specifically pyroglutamyl-phenylalanyl-glycine, designed for advanced research and development applications. This compound serves as a crucial building block and intermediate in the synthesis of more complex peptides and peptidomimetics, offering high purity and structural precision. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on drug discovery, biochemical studies, and proteomics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel therapeutic peptides and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies and proteomics research.
• Drug Discovery: Serves as a core scaffold for developing new drug candidates targeting specific receptors or enzymes.
• Peptide Library Construction: An essential component for creating combinatorial peptide libraries for high-throughput screening.
• Academic Studies: Employed in university and institutional labs for teaching and investigating peptide chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	Pglu-Phe-Gly-Oh
CAS No.	90986-81-5
Molecular Formula	C₁₉H₂₃N₃O₆
Molecular Weight	389.41 g/mol
Synonyms	Pyroglutamyl-Phenylalanyl-Glycine; Pyroglutamyl-L-Phenylalanylglycine; L-Pyroglutamyl-L-phenylalanylglycine; pGlu-Phe-Gly-OH; 5-Oxo-L-prolyl-L-phenylalanylglycine; 5-Oxoprolylphenylalanylglycine; (S)-2-((S)-2-(5-Oxopyrrolidine-2-carboxamido)-3-phenylpropanamido)acetic acid; H-pGlu-Phe-Gly-OH
EINECS	Contact for details

Quality Control

Our Pglu-Phe-Gly-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. We provide comprehensive analytical data, including HPLC chromatograms and mass spectrometry reports. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.