Description

(Met(O)27)-Grf (Human) CAS NO 90896-48-3 is a chemically modified, oxidized form of the human growth hormone-releasing factor (GRF) peptide. This specific modification is critical for advanced biochemical research, particularly in studies of protein oxidation, post-translational modifications, and receptor-ligand interactions. It is an essential reference standard and research reagent for pharmaceutical R&D, academic institutions, and biotechnology companies focused on endocrinology, peptide therapeutics, and metabolic disorder research.

Application

• Biochemical Research: Used as a key reference standard in studies of growth hormone secretagogue mechanisms and signal transduction pathways.
• Pharmaceutical Development: Serves as a critical intermediate or analytical standard in the development and quality control of peptide-based therapeutics targeting growth hormone release.
• Metabolic Studies: Employed in in vitro and in vivo research to investigate the role of methionine oxidation in peptide stability, activity, and aging-related diseases.
• Proteomics & Biomarker Discovery: Utilized in mass spectrometry and chromatography as a calibrant for identifying oxidized peptide biomarkers in complex biological samples.
• Receptor Binding Assays: Acts as a specific ligand in competitive binding studies to characterize the GHRH (Growth Hormone-Releasing Hormone) receptor.
• Quality Control & Validation: Essential for the calibration of analytical instruments (HPLC, LC-MS) and validation of assay methods in GMP/GLP environments.

Basic Information

Product Name	(Met(O)27)-Grf (Human)
CAS No.	90896-48-3
Molecular Formula	C215H366N72O67S
Molecular Weight	5039.7 g/mol
Synonyms	[Methionine Sulfoxide27]-hGRF (1-44) amide, human; Oxidized Growth Hormone-Releasing Factor (1-44) amide, human; hGRF (1-44)-NH2, Met(O)27; Sermorelin Acetate, oxidized derivative; GHRH (1-44) amide, human, Met(O)27; Growth Hormone-Releasing Hormone (1-44) amide, oxidized; GRF (human), Methionine-27 sulfoxide form; Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met(O)-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
EINECS	Contact for details

Quality Control

Our (Met(O)27)-Grf (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support development projects requiring custom purity grades or specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Aliquot into smaller working quantities after first use to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.