Description

(Des-Gly10,His(Bzl)6,Pro-Nhet9)-Lhrh is a synthetic peptide analog of Gonadotropin-Releasing Hormone (GnRH), a key regulator of the reproductive endocrine system. This modified sequence is designed for enhanced stability and specific receptor binding affinity, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in developing novel therapeutics for endocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced GnRH agonist or antagonist drug candidates.
• Endocrinology Research: Used in vitro and in vivo studies to investigate the hypothalamic-pituitary-gonadal axis, hormone regulation, and related metabolic pathways.
• Oncology Research: Applied in preclinical research for hormone-dependent cancers (e.g., prostate cancer, breast cancer) to study therapeutic mechanisms.
• Reproductive Medicine: Employed in the development of treatments for conditions such as endometriosis, uterine fibroids, and assisted reproductive technologies.
• Biochemical Standard: Acts as a reference standard or calibrant in analytical method development and quality control for peptide-based pharmaceuticals.
• Peptide Chemistry Studies: Used to study structure-activity relationships (SAR), peptide stability, and modification techniques.

Basic Information

Product Name	(Des-Gly10,His(Bzl)6,Pro-Nhet9)-Lhrh
CAS No.	90760-96-6
Molecular Formula	C₆₄H₈₃N₁₇O₁₂
Molecular Weight	1266.5 g/mol
Synonyms	Des-Gly10,His(Bzl)6,Pro-NHEt9-LHRH; GnRH Analog (Des-Gly10,His(Bzl)6,Pro-Nhet9); Luteinizing Hormone-Releasing Hormone Analog; Gonadorelin Analog; (Des-Gly10,His(Bzl)6,Pro-Nhet9)-Gonadorelin; pGlu-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt; LH-RH Derivative; Synthetic GnRH Peptide Fragment
EINECS	Contact for details

Quality Control

Our (Des-Gly10,His(Bzl)6,Pro-Nhet9)-Lhrh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our processes are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.