Description

(D-Arg2,Sar4)-Dermorphin (1-4) is a synthetic tetrapeptide analog derived from the potent natural opioid peptide dermorphin. This compound is of significant interest for research into opioid receptor pharmacology and the development of novel analgesic pathways. It serves as a critical biochemical tool for neuroscientists and pharmacologists studying pain modulation, receptor binding, and signal transduction mechanisms.

Application

• Neuroscience Research: Used as a selective ligand to study the binding affinity and functional activity of mu-opioid receptors (MOR) in vitro and in vivo.
• Pharmacological Studies: A key reference compound for investigating structure-activity relationships (SAR) of opioid peptides and developing analogs with modified potency or selectivity.
• Analgesic Mechanism Research: Employed in experimental models to understand the central and peripheral mechanisms of peptide-based pain relief.
• Biochemical Assay Development: Serves as a standard or control in receptor binding assays, cAMP accumulation tests, and other functional cellular assays.
• Academic & Institutional R&D: Essential for university laboratories and research institutes focused on neurobiology, medicinal chemistry, and peptide science.

Basic Information

Product Name	(D-Arg2,Sar4)-Dermorphin (1-4)
CAS No.	90549-86-3
Molecular Formula	C24H42N10O6
Molecular Weight	566.66 g/mol
Synonyms	H-Tyr-D-Arg-Phe-Sar-OH; [D-Arg2,Sar4]-Dermorphin (1-4) amide; Dermorphin (1-4) tetrapeptide analog; Tyr-D-Arg-Phe-Sar; D-Arg2,Sar4-Dermorphin fragment 1-4; [D-Arg2, Sar4]-Dermorphin-(1-4); Dermorphin-related tetrapeptide
EINECS	Contact for details

Quality Control

Our (D-Arg2,Sar4)-Dermorphin (1-4) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.