Description

H-Ile-Leu-Ome Hcl is a protected dipeptide derivative, specifically the methyl ester hydrochloride salt of the Ile-Leu dipeptide. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptide sequences. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in developing novel therapeutic peptides, bioactive probes, and other advanced biomolecules.

Application

• Pharmaceutical Intermediate: A key raw material in the research and development of novel peptide-based therapeutics.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid segment for the efficient, sequential assembly of target peptide chains.
• Biochemical Research: Employed in studies of protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Peptide Library Construction: Essential for creating combinatorial libraries for high-throughput screening in drug discovery.
• Custom Peptide Production: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and biochemistry.

Basic Information

Item	Detail
Product Name	H-Ile-Leu-Ome Hcl
CAS No.	90315-79-0
Molecular Formula	C15H29N3O4 • HCl
Molecular Weight	351.87 g/mol (free base: 315.41 g/mol)
Synonyms	Isoleucyl-Leucine Methyl Ester Hydrochloride; H-Ile-Leu-OMe • HCl; Ile-Leu-OMe HCl; L-Isoleucyl-L-leucine methyl ester hydrochloride; Methyl L-isoleucyl-L-leucinate hydrochloride; N-(2S,3S)-2-Amino-3-methylpentanoyl-L-leucine methyl ester hydrochloride; Peptide Synthesis Building Block Fmoc-Ile-Leu-OMe precursor
EINECS	Contact for details

Quality Control

Every batch of H-Ile-Leu-Ome Hcl is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for peptide synthesis. A Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters is supplied with each shipment. Our quality protocols are designed to support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-L isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.