Description

5-(2-Chloroethyl)-2'-Fluoroarabinofuranosyluracil is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and DNA/RNA synthesis pathways.
• Antiviral Drug Development: Investigated for its potential activity against DNA viruses, including herpesviruses and hepatitis B virus (HBV).
• Oncology Research: Explored for its cytotoxic properties and potential application in chemotherapy regimens, particularly for solid tumors.
• Radiopharmaceutical Precursor: Can be utilized in the development of fluorinated tracers for Positron Emission Tomography (PET) imaging.
• Academic & Contract Research: Employed in university and CRO settings for structure-activity relationship (SAR) studies of modified nucleosides.

Basic Information

Product Name	5-(2-Chloroethyl)-2'-Fluoroarabinofuranosyluracil
CAS No.	90301-73-8
Molecular Formula	C11H13ClFN2O6
Molecular Weight	320.68 g/mol
Synonyms	2'-Fluoro-5-(2-chloroethyl)arabinofuranosyluracil; 1-((2R,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(2-chloroethyl)pyrimidine-2,4(1H,3H)-dione; 5-(2-Chloroethyl)-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; FCAU; 2'-F-5-(2-Chloroethyl) ara-U; FEAC; 2'-Fluoro-5-(2-chloroethyl)-1-β-D-arabinofuranosyluracil
EINECS	Contact for details

Quality Control

Our 5-(2-Chloroethyl)-2'-Fluoroarabinofuranosyluracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.