Description

5-(2-Chloroethyl)-1-[(2S,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl ]Pyrimidine-2,4-Dione is a high-purity nucleoside analog derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, where precise stereochemistry and purity are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside-based therapeutics, requiring a reliable and consistent supply of high-quality intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of potential therapeutic agents against a range of DNA and RNA viruses.
• Anticancer Agent Development: Serves as a scaffold for creating compounds that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleoside metabolism pathways.
• Process Chemistry & Scale-up: Used in optimizing synthetic routes for the commercial production of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	5-(2-Chloroethyl)-1-[(2S,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl ]Pyrimidine-2,4-Dione
CAS No.	90301-59-0
Molecular Formula	C11H15ClN2O6
Molecular Weight	306.70 g/mol
Synonyms	5-(2-Chloroethyl)-1-[(2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 5-(2-Chloroethyl)uridine derivative; 1-((2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(2-chloroethyl)pyrimidine-2,4(1H,3H)-dione; 5-(2-Chloroethyl)-1-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Modified Uridine Derivative; Chloroethyl Uridine Analog; Nucleoside Intermediate 90301-59-0
EINECS	Contact for details

Quality Control

Our 5-(2-Chloroethyl)-1-[(2S,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl ]Pyrimidine-2,4-Dione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.