Description

L-Proline, 4-Hydroxy-1-Propyl-, trans- (9Ci) CAS NO 90245-00-4 is a specialized, non-proteinogenic proline derivative characterized by a trans-configuration hydroxypropyl side chain. This compound matters as a high-value chiral building block and intermediate for advanced organic synthesis, offering unique structural features for modulating peptide conformation and biological activity. It is primarily needed by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers developing novel active ingredients, peptidomimetics, and catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic programs.
• Peptidomimetics & Conformational Studies: Used to introduce structural constraints and modify the backbone of peptides to enhance stability, bioavailability, and receptor selectivity.
• Agrochemical Synthesis: Serves as a sophisticated intermediate in the production of advanced, chiral active ingredients for crop protection.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel organocatalysts and chiral ligands for asymmetric synthesis.
• Biochemical Research: Utilized as a probe or standard in enzymatic studies and metabolic pathway investigations.
• Specialty Fine Chemicals: Acts as a building block for high-value, custom-synthesized compounds in contract research and manufacturing.

Basic Information

Product Name	L-Proline, 4-Hydroxy-1-Propyl-, trans- (9Ci)
CAS No.	90245-00-4
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	trans-4-Hydroxy-1-propyl-L-proline; (2S,4R)-4-Hydroxy-1-propylpyrrolidine-2-carboxylic acid; 1-Propyl-4-hydroxy-L-proline; L-1-Propyl-4-hydroxyproline; 4-Hydroxy-1-propylproline; (4R)-1-Propyl-4-hydroxy-L-proline; 4-Hydroxy-1-n-propyl-L-proline; 90245-00-4
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-1-Propyl-, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as chiral purity, assay, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.