Description

2,4-Dichloro-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its versatile reactivity, where the chlorine atoms serve as excellent leaving groups for nucleophilic aromatic substitution, enabling the construction of complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors (e.g., JAK, BTK inhibitors) and other small-molecule drug candidates targeting cancer and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for developing chemical probes and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Investigated as a building block for organic electronic materials and functional dyes due to its electron-deficient pyrrolopyrimidine core.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of bespoke compounds and advanced intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	2,4-Dichloro-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	90213-67-5
Molecular Formula	C7H5Cl2N3
Molecular Weight	202.04 g/mol
Synonyms	7-Methyl-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine; 2,4-Dichloro-7-methylpyrrolo[2,3-d]pyrimidine; Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-7-methyl-; 90213-67-5; 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-7-methyl-
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard material meets research-grade specifications, and we offer capabilities for custom synthesis under higher purity grades, including cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption, which could affect stability and reactivity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.