Description

Angiotensin II, Ile(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at the 8th position with an isoleucine residue. This compound is of significant value for biochemical and pharmacological research, serving as a critical tool for studying the renin-angiotensin system (RAS), receptor binding, and cardiovascular physiology. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on hypertension, heart failure, and metabolic disorder research.

Application

• Biochemical Research: Used as a reference standard and active ligand in studies of the renin-angiotensin-aldosterone system (RAAS).
• Pharmacological Studies: Employed in receptor binding assays and functional studies to investigate Angiotensin II receptor (AT1 & AT2) activity and signal transduction pathways.
• Drug Discovery & Development: Serves as a key intermediate or reference compound in the development of novel cardiovascular therapeutics and receptor antagonists.
• In Vitro Diagnostics: Utilized in the development and calibration of immunoassays (e.g., ELISA) for detecting and quantifying angiotensin-related peptides.
• Cell Culture & Physiology: Applied in cellular models to study the effects of angiotensin signaling on vascular smooth muscle contraction, aldosterone secretion, and blood pressure regulation.
• Metabolic Research: Investigated for its role in fluid-electrolyte balance, thirst mechanisms, and interactions with other hormonal systems.

Basic Information

Item	Detail
Product Name	Angiotensin II, Ile(8)-
CAS No.	9088-02-2
Molecular Formula	C50H71N13O12
Molecular Weight	1022.2 g/mol
Synonyms	Ile8-Angiotensin II; [Ile8]-Angiotensin II; Angiotensin II (Ile8); Asp-Arg-Val-Tyr-Ile-His-Pro-Ile; 5-Isoleucine-angiotensin II; DRVYIHPI; Saralasin Acetate related compound; Angiotensin II receptor ligand
EINECS	Contact for details

Quality Control

Our Angiotensin II, Ile(8)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.