Description

1-Sarcosine-8-Isoleucine Angiotensin II is a synthetic peptide analog of the potent vasoconstrictor hormone Angiotensin II, featuring specific amino acid substitutions at positions 1 and 8. This modification is critical for research into the renin-angiotensin system (RAS), receptor binding studies, and the development of novel therapeutic agents targeting cardiovascular and renal functions. It is an essential biochemical tool for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on hypertension, heart failure, and metabolic disorder research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation.
• Receptor Pharmacology: Critical for in vitro and in vivo assays to characterize Angiotensin II receptor (AT1 and AT2) subtype specificity, affinity, and signaling pathways.
• Drug Discovery & Development: Serves as a key intermediate or pharmacological tool in the design and screening of novel receptor antagonists and modulators for cardiovascular diseases.
• Enzyme Activity Studies: Employed in research on angiotensin-converting enzyme (ACE) and other peptidases to understand peptide metabolism and stability.
• Cell Signaling & Physiology: Applied in cellular models to investigate the effects of Angiotensin II analogs on vascular smooth muscle contraction, aldosterone secretion, and cellular proliferation.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits for measuring components of the RAAS pathway.

Basic Information

Product Name	1-Sarcosine-8-Isoleucine Angiotensin II
CAS No.	9088-01-1
Molecular Formula	C49H69N13O11
Molecular Weight	1032.2 g/mol
Synonyms	Sar1,Ile8-Angiotensin II; [Sar1,Ile8]-Ang II; Sarmesin; Angiotensin II (1-8) heptapeptide, 1-sarcosine-8-isoleucine; [Sar1, Ile8] All; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH
EINECS	Contact for details

Quality Control

Every batch of 1-Sarcosine-8-Isoleucine Angiotensin II is manufactured and analyzed under strict quality management protocols. We ensure high purity and consistency through comprehensive analytical techniques including HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and peptide content. Our quality system supports research and development requiring reliable, well-characterized biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the product desiccated. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.