Description

Urokinase CAS NO 9067-58-7 is a serine protease enzyme, also known as urokinase-type plasminogen activator (uPA), which plays a critical role in the fibrinolytic system by converting plasminogen to plasmin. This action is essential for the breakdown of blood clots, making it a vital therapeutic agent. It is primarily required by the pharmaceutical and biotechnology industries for the production of thrombolytic drugs, research into cardiovascular diseases, and as a key reagent in biochemical and cell culture applications.

Application

• Thrombolytic Therapy: Active pharmaceutical ingredient (API) in medications for acute myocardial infarction, pulmonary embolism, and peripheral arterial occlusion.
• Biomedical Research: Used as a tool enzyme in studies of the plasminogen activation system, cell migration, tissue remodeling, and cancer metastasis.
• Diagnostic Reagents: A key component in in-vitro diagnostic kits for assessing fibrinolytic activity and related coagulation disorders.
• Cell Culture & Tissue Engineering: Employed to dissociate cells from tissues and to study extracellular matrix degradation in various experimental models.
• Biochemical Processing: Used in specific proteolytic cleavage processes within downstream biomanufacturing.

Basic Information

Product Name	Urokinase
CAS No.	9067-58-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Urokinase-type Plasminogen Activator (uPA); Plasminogen Activator, Urokinase; EC 3.4.21.73; Uronase; Abbokinase; Win-Kinase; UK; u-PA
EINECS	Contact for details

Quality Control

Our Urokinase is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including activity assays, purity profiling, and sterility checks where applicable, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) with detailed test results are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms
Specific Activity	> 100,000 IU/mg protein
Purity (HPLC)	> 98.0%
Protein Content (Biuret)	Contact for details
pH (Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.