Description

Urotensin Ii CAS NO 9047-55-6 is a synthetic peptide analog of the potent vasoactive hormone, urotensin II. This compound is a critical research tool for investigating the urotensinergic system, which plays a significant role in cardiovascular regulation and related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, metabolic disorders, and novel drug discovery.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of the UT receptor (GPR14) to understand its role in vasoconstriction, cardiac function, and fibrosis.
• Drug Discovery & Development: Serves as a key molecular tool for high-throughput screening (HTS) assays to identify and characterize urotensin II receptor agonists or antagonists.
• Biochemical Studies: Employed in receptor binding assays, signal transduction pathway analysis, and second messenger system investigations (e.g., calcium mobilization, IP3 accumulation).
• In Vitro & Ex Vivo Models: Applied in cell-based assays and isolated tissue/organ preparations to study vascular tone and smooth muscle contraction.
• Academic Research: Fundamental for exploring the physiological and pathophysiological roles of the urotensin system in cardiovascular, renal, and central nervous system functions.
• Diagnostic Development: Potential use in the development of immunoassays or other diagnostic methods for conditions linked to urotensin II dysregulation.

Basic Information

Product Name	Urotensin Ii
CAS No.	9047-55-6
Molecular Formula	C106H146N28O28S2
Molecular Weight	~ 2388.6 g/mol
Synonyms	Urotensin II (human); hUII; UII; Urotensin-2; U-II; GPR14 Ligand; Urotensin II Peptide; Cyclo(-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val)
EINECS	Contact for details

Quality Control

Our Urotensin Ii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider lyophilized powder under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Within ± 10% of theoretical values
Solvent Residues	Meets ICH guidelines
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.