Description

Ancrod is a purified serine protease enzyme derived from the venom of the Malayan pit viper (*Calloselasma rhodostoma*). This compound is of significant interest for its potent and specific fibrinogenolytic activity, which cleaves fibrinogen to produce a non-crosslinked fibrin that is rapidly cleared from circulation. It is primarily utilized in life science research and pharmaceutical development, particularly in studies related to thrombosis, hemostasis, and as a potential therapeutic agent for conditions requiring controlled defibrinogenation.

Application

• Biochemical Research: A critical tool for studying blood coagulation mechanisms, platelet aggregation, and fibrinolysis in vitro.
• Pharmaceutical Development: Investigated as an active pharmaceutical ingredient (API) for antithrombotic therapies and in the management of acute ischemic stroke.
• Diagnostic Reagent Production: Used in the formulation of specialized diagnostic kits for assessing fibrinogen levels and clotting disorders.
• Neuroscience Studies: Employed in experimental models to induce controlled defibrinogenation, helping to study its effects on blood flow and neuroprotection.
• Standard Reference Material: Serves as a high-purity standard for calibrating assays and validating analytical methods in clinical laboratories.

Basic Information

Product Name	Ancrod
CAS No.	9046-56-4
Molecular Formula	Contact for details
Molecular Weight	~35,000 Da (Approximate)
Synonyms	Arvin; Arwin; Venacil; Defibrase; Serine protease ancrod; EC 3.4.21.74; Coagulation factor IIa-like enzyme; *Calloselasma rhodostoma* venom serine proteinase; Fibrinogenase ancrod
EINECS	Contact for details

Quality Control

Our Ancrod is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as enzymatic activity, purity by HPLC, and endotoxin levels. We adhere to relevant quality management systems to guarantee batch-to-batch consistency and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/Activity)	Conforms
Specific Activity	≥ 150 NIH units/mg protein
Purity (HPLC)	≥ 95.0%
Protein Content (Biuret)	≥ 90.0%
Endotoxin	< 10 EU/mg
Solubility	Soluble in water or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.