Description

Angiotensin I is a crucial decapeptide hormone that serves as the direct precursor to the potent vasoconstrictor Angiotensin II. This compound is fundamental for research into the Renin-Angiotensin-Aldosterone System (RAAS), a key regulator of blood pressure and fluid balance. It is essential for pharmaceutical R&D, biochemical studies, and the development of diagnostic assays targeting cardiovascular and renal diseases.

Application

• Biomedical Research: Critical substrate for studying the enzymatic activity of Angiotensin-Converting Enzyme (ACE) and the broader RAAS pathway.
• Pharmaceutical Development: Used in the screening and validation of novel ACE inhibitors and other antihypertensive drug candidates.
• Diagnostic Reagents: Serves as a key component in enzyme immunoassays (EIAs) and radioimmunoassays (RIAs) for clinical diagnostics.
• Biochemical Standard: Acts as a high-purity reference standard for quantitative analysis and method calibration in analytical laboratories.
• Cell Culture & Physiology Studies: Employed in in vitro models to investigate cellular responses and signaling mechanisms related to cardiovascular function.

Basic Information

Product Name	Angiotensin I
CAS No.	9041-90-1
Molecular Formula	C62H89N17O14
Molecular Weight	1296.5 g/mol
Synonyms	Angiotensin I (human, mouse, rat); Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu; DRVYIHPFHL; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH; 1-L-Aspartic acid 5-L-valine-10-L-leucineangiotensin I; Hypertensin I
EINECS	Contact for details

Quality Control

Our Angiotensin I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific purity requirements (e.g., >95%, >98%) are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.