Description

Proinsulin CAS NO 9035-68-1 is a single-chain polypeptide precursor to the vital hormone insulin. This compound is of critical importance in biochemical and pharmaceutical research for studying insulin biosynthesis, processing, and diabetes-related mechanisms. It is primarily utilized by research institutions, diagnostic manufacturers, and biopharmaceutical companies engaged in metabolic disorder research and therapeutic development.

Application

• Biochemical Research: Fundamental studies on insulin synthesis, folding, and post-translational modification pathways.
• Diabetes Research: Investigation of β-cell function and dysfunction, serving as a key biomarker and research tool.
• Diagnostic Reagent Production: Used as a standard or antigen in immunoassays for measuring insulin and proinsulin levels in clinical diagnostics.
• Pharmaceutical Development: A reference material in the development and quality control of insulin and insulin analog therapeutics.
• Cell Biology Studies: Exploration of secretory pathways and protein processing within pancreatic beta cells and other recombinant systems.
• Educational & Reference Standard: Serves as a high-purity standard in academic and industrial laboratory settings.

Basic Information

Product Name	Proinsulin
CAS No.	9035-68-1
Molecular Formula	C257H383N65O77S6
Molecular Weight	~9397.5 g/mol
Synonyms	Proinsulin (human); Human Proinsulin; Insulin Precursor; Proinsulin Recombinant Human; Pro-Insulin; INS; Preproinsulin (processed form)
EINECS	Contact for details

Quality Control

Our Proinsulin is produced and tested under stringent quality management systems. Each batch is characterized to ensure identity, purity, and biological activity, meeting the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by mass spectrometry and peptide mapping), endotoxin levels, and bioactivity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (Karl Fischer)	≤ 5.0%
Biological Activity	Assessed by immunoassay
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.