Description

Hemoglobin-A2 is a specialized hemoglobin variant, a tetrameric protein composed of two alpha and two delta globin chains. This compound is of significant interest in clinical diagnostics and biochemical research for its role as a key biomarker. It is primarily required by diagnostic manufacturers, clinical laboratories, and research institutions for the development of assays and the study of hemoglobinopathies.

Application

• Clinical Diagnostic Kits: Essential raw material for the manufacturing of in-vitro diagnostic (IVD) reagents and calibrators used in hemoglobinopathy testing.
• Biochemical Research: Used as a standard or substrate in studies of hemoglobin structure, function, and genetic disorders like β-thalassemia.
• Quality Control (QC) Material: Serves as a critical component in QC materials for hematology analyzers to ensure accurate measurement of HbA2 levels.
• Reference Standard: Employed as a high-purity reference standard in chromatography (HPLC, CE) and electrophoresis methods for quantitative analysis.
• Therapeutic Development: Investigated in research for potential therapeutic applications and understanding oxygen transport mechanisms.

Basic Information

Product Name	Hemoglobin-A2
CAS No.	9034-53-1
Molecular Formula	C~2952H~4664N~812O~832S~40Fe4
Molecular Weight	~64,500 Da (for α2δ2 tetramer)
Synonyms	Hb A2; Hemoglobin A2; α2δ2 Hemoglobin; δ-Beta Globin Tetramer; Minor Adult Hemoglobin; Hemoglobin Variant A2; Deoxyhemoglobin A2 (reduced form); Oxyhemoglobin A2 (oxygenated form)
EINECS	Contact for details

Quality Control

Our Hemoglobin-A2 is produced and tested under stringent quality management systems. Each batch is characterized for identity, purity, and biological activity using advanced analytical techniques including HPLC, electrophoresis, and spectrophotometry. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), spectral properties, and functional data is provided with every shipment to ensure it meets the exacting standards required for diagnostic and research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For in-use stability, follow specific protocol recommendations.

Specification

Item	Specification
Appearance	Dark red to brown lyophilized powder
Identification (HPLC/Electrophoresis)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret/Spectrophotometric)	≥ 90%
Methemoglobin Content	≤ 5%
Solubility	Clear solution in buffer
Water Content (Karl Fischer)	≤ 5.0%
Biological Activity (Oxygen Binding)	Evaluated by spectrophotometry

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.