Description

Long-Acting Thyroid Stimulator (LATS) is a specific immunoglobulin associated with certain autoimmune thyroid conditions, primarily Graves' disease. This compound is of significant interest in endocrinology and immunology research for its role in mimicking the action of thyroid-stimulating hormone (TSH). It serves as a critical reference material and research tool for diagnostic development, autoimmune disease studies, and the investigation of thyroid receptor pathways in pharmaceutical R&D.

Application

• Biomedical Research: Fundamental studies on the pathogenesis and mechanisms of autoimmune thyroid disorders, including Graves' disease.
• Diagnostic Assay Development: Used as a reference standard or calibrator in the development and validation of immunoassays for detecting thyroid autoantibodies.
• Pharmaceutical R&D: Investigation of drug candidates targeting the TSH receptor or modulating autoimmune responses in thyroid pathology.
• Clinical Studies: A key analyte in longitudinal studies monitoring disease activity and treatment efficacy in patients with thyroid autoimmunity.
• Quality Control in Diagnostics: Serves as a critical quality control reagent for manufacturers of thyroid function test kits to ensure assay accuracy and reproducibility.

Basic Information

Product Name	Long-Acting Thyroid Stimulator
CAS No.	9034-48-4
Molecular Formula	N/A (Immunoglobulin)
Molecular Weight	Approx. 150 kDa (IgG)
Synonyms	LATS; Long-Acting Thyroid Stimulator Immunoglobulin; Graves' Disease Immunoglobulin; Thyroid-Stimulating Immunoglobulin (TSI); Human Thyroid Stimulator; TSH Receptor Antibody; Thyrotropin-Binding Inhibitory Immunoglobulin (TBII); Anti-TSH Receptor Antibody
EINECS	Contact for details

Quality Control

Our Long-Acting Thyroid Stimulator is produced and handled under stringent quality management protocols. Each batch is characterized for identity, purity, and biological activity using advanced analytical techniques. Certificates of Analysis (COA) detailing specific results for identity, purity (by HPLC/SDS-PAGE), and functional activity are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Aliquot as recommended to maintain activity.

Specification

Item	Specification
Appearance	Lyophilized powder or clear solution
Identification (Immunoassay)	Positive for TSH receptor binding
Purity (SDS-PAGE)	> 90% (under reducing conditions)
Protein Content	Determined by UV absorbance or BCA assay
Biological Activity	Assessed by cAMP response in thyroid cell lines
Endotoxin Level	< 1.0 EU/mg (where applicable)
Solvent (if applicable)	PBS or other specified buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.