Description

Antistreptohyaluronidase is a purified enzyme preparation derived from bacterial sources, specifically targeting hyaluronic acid. This product is critical for research and diagnostic applications where the precise quantification or neutralization of hyaluronidase activity is required. It is primarily utilized by biotechnology firms, clinical research laboratories, and diagnostic kit manufacturers for studying bacterial pathogenesis and developing analytical assays.

Application

• Diagnostic Reagent Manufacturing: A key component in diagnostic kits for the detection and titration of anti-streptolysin O (ASO) antibodies, aiding in the diagnosis of post-streptococcal sequelae like rheumatic fever.
• Biomedical Research: Used as a specific inhibitor in enzymatic studies to investigate the role of streptococcal hyaluronidase in tissue invasion and the degradation of the extracellular matrix.
• Immunology Studies: Employed in serological tests to measure neutralizing antibodies in patient serum samples, providing insights into immune response to streptococcal infections.
• Enzyme Standardization: Serves as a reference standard for calibrating hyaluronidase activity assays, ensuring consistency and accuracy in laboratory measurements.
• Vaccine Development: Used in research for characterizing bacterial antigens and evaluating vaccine candidates against Streptococcus pyogenes.

Basic Information

Product Name	Antistreptohyaluronidase
CAS No.	9013-30-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Anti-streptococcal hyaluronidase; Streptococcal hyaluronidase inhibitor; ASH; Hyaluronidase neutralizing antibody; Anti-hyaluronidase; Streptomyces hyalurolyticus enzyme inhibitor
EINECS	Contact for details

Quality Control

Our Antistreptohyaluronidase is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing for activity, purity, and specificity to ensure it meets the exacting standards required for research and in-vitro diagnostic use. Certificates of Analysis (COA) detailing potency, protein content, and absence of contaminating activities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to maintain stability and activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Positively neutralizes hyaluronidase activity
Potency (Activity)	≥ [Value] Units/mg protein
Protein Content (Biuret)	Contact for details
Purity (SDS-PAGE)	≥ 90%
pH (in solution)	6.0 - 7.5
Endotoxin (LAL)	< 1.0 EU/mg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.