Description

Protamine CAS NO 9012-00-4 is a low molecular weight, highly basic protein derived primarily from the sperm of salmon and other fish species. It is a critical pharmaceutical agent, most notably used as a heparin antagonist to reverse the anticoagulant effects of heparin following surgical procedures like cardiopulmonary bypass. This product is essential for manufacturers in the pharmaceutical and biotechnology sectors, particularly those producing injectable anticoagulant reversal drugs, formulating drug delivery systems, and conducting biochemical research.

Application

• Heparin Antagonism: The primary and most critical application is the neutralization of heparin's anticoagulant activity in clinical settings post-surgery.
• Pharmaceutical Formulations: Used as an active pharmaceutical ingredient (API) in sterile injectable products for heparin overdose reversal.
• Drug Delivery: Serves as a complexing agent in the development of sustained-release formulations, particularly for insulin (e.g., NPH insulin) and other peptides.
• Biotechnology & Research: Employed in molecular biology for DNA precipitation and purification, and in cell culture applications.
• Food Industry: Occasionally used as a clarifying agent in the production of beer and wine.

Basic Information

Product Name	Protamine
CAS No.	9012-00-4
Molecular Formula	Mixture of proteins (primarily protamine sulfate)
Molecular Weight	~4000 - 6000 Da (Approximate average)
Synonyms	Protamine Sulfate; Salmine; Clupeine; Iletin; Heparin antagonist; Protaminum; Protamine (from salmon); 9012-00-4
EINECS	Contact for details

Quality Control

Our Protamine is manufactured and tested to meet stringent pharmaceutical standards. Quality is assured through a comprehensive battery of tests including identity, purity, potency, and safety profiles. Certificates of Analysis (COA) documenting compliance with relevant specifications such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia) are available upon request, ensuring reliability for critical medical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Assay (Nitrogen)	20.0% - 25.0%
Potency (Heparin Neutralization)	Meets USP/EP requirements
pH (Solution)	6.0 - 7.5
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Bacterial Endotoxins	< 3.0 IU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.