Description

Thyroglobulin, Human is a high-purity glycoprotein that serves as the precursor for the synthesis of thyroid hormones thyroxine (T4) and triiodothyronine (T3). Its consistent quality and biological relevance make it an essential reference standard and critical raw material in diagnostic and research applications. This product is primarily required by manufacturers of in-vitro diagnostic (IVD) kits, clinical research organizations, and biopharmaceutical companies focused on endocrine system studies and autoimmune disease research.

Application

• Immunoassay Calibration & Control: Serves as a primary calibrator and quality control material in immunoassays for measuring anti-thyroglobulin antibodies (TgAb), a key marker for autoimmune thyroid disorders like Hashimoto's thyroiditis and Graves' disease.
• Diagnostic Kit Manufacturing: A critical antigen component in the production of enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and radioimmunoassay (RIA) kits for thyroid function testing.
• Clinical Research & Biomarker Studies: Used as a standard in research investigating thyroid cancer biomarkers, as thyroglobulin levels are monitored in post-thyroidectomy patients to detect recurrence.
• Antigen for Antibody Production: Employed to immunize animals for the generation of polyclonal and monoclonal antibodies specific to human thyroglobulin, which are then used in various diagnostic and research tools.
• Reference Standard in Pharmaceutical QC: Acts as a well-characterized biological reference standard in quality control laboratories to ensure the accuracy and precision of thyroid-related diagnostic products.
• Autoimmunity Research: Utilized in studies to understand the pathogenesis of autoimmune thyroid diseases and to evaluate potential therapeutic interventions.

Basic Information

Product Name	Thyroglobulin, Human
CAS No.	9010-34-8
Molecular Formula	Contact for details
Molecular Weight	~660 kDa
Synonyms	Human Thyroglobulin; Tg; Thyroglobulin (Human); Thyroglobulin Precursor; TGN; Antigen Tg; Thyroid Colloid Protein; Autoantigen TG
EINECS	Contact for details

Quality Control

Our Human Thyroglobulin is produced and tested under stringent quality management systems. Each batch is characterized for identity, purity, and immunological activity to ensure it meets the exacting requirements of the diagnostic and research industries. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as purity (by SDS-PAGE and HPLC), protein concentration, endotoxin levels, and performance in functional immunoassays.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquotting upon receipt is recommended for extended use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunodiffusion)	Positive for Human Thyroglobulin
Purity (SDS-PAGE)	≥ 95%
Protein Content (Biuret)	≥ 90%
Immunological Activity (ELISA)	Reactive with standard anti-Tg antibodies
Endotoxin (LAL)	< 1.0 EU/mg
Solubility	Soluble in water or neutral buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.