Description

Rheumatoid Factor CAS NO 9009-79-4 is a critical autoantibody, primarily of the IgM class, that targets the Fc region of IgG. It serves as a key serological marker in the diagnosis and monitoring of autoimmune conditions. This reagent is essential for clinical diagnostics, pharmaceutical research, and immunology studies. Its reliable detection is fundamental for assessing disease activity and guiding therapeutic decisions in rheumatoid arthritis and related disorders.

Application

• Clinical Diagnostic Assays: Primary component in ELISA, nephelometry, and latex agglutination test kits for the detection of Rheumatoid Factor in human serum or plasma.
• Autoimmune Disease Research: Used as a standard or control in studies investigating the pathogenesis, progression, and serological profiles of rheumatoid arthritis (RA) and other connective tissue diseases.
• IVD Kit Manufacturing: Serves as a calibrated antigen in the production and quality control of in-vitro diagnostic (IVD) reagents and devices.
• Pharmaceutical Development: Employed in bioanalytical testing during drug development for autoimmune therapies to monitor patient immune responses.
• Laboratory Quality Control: Acts as a reference material for the calibration of analytical instruments and the validation of testing procedures in clinical laboratories.
• Academic & Biomedical Research: Utilized in immunological studies to understand antibody-antigen interactions, immune complex formation, and B-cell activity.

Basic Information

Product Name	Rheumatoid Factor
CAS No.	9009-79-4
Molecular Formula	N/A (Complex Biological Protein)
Molecular Weight	~950 kDa (IgM pentamer)
Synonyms	RF
Rheumatoid Factor Antibody
Anti-IgG Antibody (IgM)
Rheumatoid Factor (Human)
RA Factor
IgM Rheumatoid Factor
Anti-Fc IgG Antibody
EINECS	Contact for details

Quality Control

Our Rheumatoid Factor is manufactured and tested under stringent quality management systems. Each lot is characterized for specific activity, purity, and immunological reactivity to ensure batch-to-batch consistency and performance in diagnostic applications. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as titer, specificity, and stability. Production adheres to relevant guidelines for biological source materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. Avoid repeated freeze-thaw cycles. Keep the product in its original packaging until use to maintain integrity.

Specification

Item	Specification
Source	Human
Form	Lyophilized powder or Liquid
Purity	>95% (by SDS-PAGE)
Activity (Titer)	Defined IU/mL (Lot-specific)
Specificity	Reactive with human IgG Fc
Appearance	White to off-white powder or clear solution
Solubility	Soluble in buffered saline or assay diluent
Preservative	None (or specified, e.g., 0.09% Sodium Azide)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.