Description

C-Reactive Protein (CRP) is a critical acute-phase plasma protein synthesized by the liver, serving as a highly sensitive, non-specific biomarker for systemic inflammation and tissue damage. Its rapid and pronounced increase in concentration in response to inflammatory stimuli makes it an indispensable tool for clinical diagnostics and biomedical research. This high-purity protein is essential for manufacturers of in-vitro diagnostic (IVD) kits, clinical research organizations, and academic institutions focused on immunology, cardiology, and infectious disease studies.

Application

• Clinical Diagnostic Reagents: Primary calibrant and control material for immunoturbidimetric, nephelometric, and ELISA-based assays quantifying CRP levels in human serum.
• Cardiovascular Risk Assessment: Key component in high-sensitivity CRP (hs-CRP) tests used to evaluate low-grade inflammation and predict the risk of future cardiovascular events.
• Biomedical Research: Used as a standard in studies investigating the role of innate immunity, the acute-phase response, and inflammation in various disease models.
• Quality Control & Calibration: Serves as a reference standard for the validation and quality control of automated clinical chemistry analyzers in hospital and reference laboratories.
• Antibody Production & Validation: Employed as an immunogen for generating anti-CRP antibodies and for validating the specificity of immunological reagents.
• Inflammation Monitoring: Used in research applications to monitor the progression of inflammatory diseases, such as rheumatoid arthritis, and the efficacy of anti-inflammatory therapies.

Basic Information

Product Name	C-Reactive Protein
CAS No.	9009-76-1
Molecular Formula	N/A (Protein)
Molecular Weight	~115 kDa (pentameric form)
Synonyms	CRP; C-Reactive Protein, Human; Pentraxin 1; PTX1; Acute-Phase Protein; CRP Protein; Human C-Reactive Protein; Native Human CRP
EINECS	Contact for details

Quality Control

Our C-Reactive Protein is manufactured and purified under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity assessment via SDS-PAGE and HPLC, functional activity verification, and endotoxin level testing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, concentration, and specific activity is provided with every shipment, ensuring compliance with standards suitable for in-vitro diagnostic and research use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly in a dry environment after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunodiffusion/ELISA)	Positive for Human CRP
Purity (SDS-PAGE)	≥ 95%
Assay (Immunoassay)	90% - 110% of stated concentration
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in PBS or Tris buffer, pH 7.2-7.4
Biological Activity	Confirmed by calcium-dependent ligand binding

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.