Description

Heparin Potassium is a highly purified, sulfated glycosaminoglycan anticoagulant derived from porcine intestinal mucosa. This critical active pharmaceutical ingredient (API) is essential for its potent ability to inhibit blood coagulation by activating antithrombin III. It is a fundamental raw material for manufacturers in the pharmaceutical and biopharmaceutical sectors, particularly for producing injectable anticoagulant therapies, research reagents, and in-vitro diagnostic kits. Its consistent quality and reliable activity are paramount for ensuring the safety and efficacy of final medical products.

Application

• Primary Active Pharmaceutical Ingredient (API) for the manufacture of injectable anticoagulant and antithrombotic drugs.
• Key component in the production of low molecular weight heparin (LMWH) derivatives.
• Essential reagent in in-vitro diagnostic kits and clinical laboratory assays for blood coagulation studies.
• Used in cell culture and biochemistry research as a growth factor binding agent.
• Coating agent for medical devices, such as catheters and stents, to impart hemocompatibility.
• Stabilizing agent for various enzymes and proteins in bioprocessing.
• Starting material for further chemical modification and heparin-based drug discovery.

Basic Information

Product Name	Heparin Potassium
CAS No.	9005-48-5
Molecular Formula	(C12H16NS2O19S3)n
Molecular Weight	~3000-30000 Da (Average)
Synonyms	Heparin Potassium Salt; Heparin K; Potassium Heparinate; Heparinic Acid Potassium Salt; Heparin Potassium (Porcine); Anticoagulant Heparin Potassium; USP Heparin Potassium; Heparin Potassium API
EINECS	232-681-7

Quality Control

Our Heparin Potassium is manufactured and tested under strict quality systems to meet or exceed relevant pharmacopoeial standards, including USP and EP monographs. Each batch undergoes comprehensive analytical testing for identity, potency (anti-Factor IIa and anti-Factor Xa activity), purity, and specific impurities. Certificates of Analysis (COA) detailing all test results are provided to ensure full traceability and compliance with cGMP guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, storage at 2-8°C is recommended.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (Potassium)	Conforms
pH (Solution)	5.0 - 7.5
Clarity & Color of Solution	Conforms
Specific Optical Rotation	+35° to +45°
Protein	≤ 0.1% (w/w)
Nitrogen Content	1.3% - 2.5%
Sulfur Content	≥ 10.0%
Heavy Metals	≤ 30 ppm
Loss on Drying	≤ 5.0%
Residue on Ignition (Sulfated Ash)	28.0% - 41.0%
Bacterial Endotoxins	< 0.03 IU/anti-Xa IU
Assay (Potency)	≥ 180 USP Units/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.