Description

Coagulation Factor XII, Human is a high-purity plasma-derived glycoprotein that plays a critical initiating role in the intrinsic pathway of blood coagulation. Its primary commercial value lies in its essential function as a key reagent for in-vitro diagnostic (IVD) assays and life science research into hemostasis and thrombosis. This product is vital for manufacturers of coagulation analyzers, clinical diagnostic kits, and research institutions focused on hematology and vascular biology. We supply this critical reagent with a commitment to consistent activity, high purity, and reliable lot-to-lot performance for your demanding applications.

Application

• In-Vitro Diagnostic (IVD) Reagents: A critical component in the manufacturing of calibration standards, quality control materials, and test kits for activated partial thromboplastin time (aPTT) and other coagulation factor assays.
• Clinical Research & Assay Development: Used as a reference standard in research studies investigating coagulation disorders, such as Factor XII deficiency (Hageman factor deficiency), and in the development of new diagnostic methodologies.
• Hematology & Thrombosis Research: Essential for studying the contact activation pathway, kallikrein-kinin system, fibrinolysis, and inflammatory responses linked to coagulation.
• Pharmaceutical R&D: Employed in screening and evaluating potential antithrombotic or pro-coagulant drug candidates that target the intrinsic pathway.
• Biochemical Reagent: Serves as a purified enzyme substrate for enzymatic studies and for investigating protein-protein interactions within the coagulation cascade.

Basic Information

Item	Detail
Product Name	Coagulation Factor XII, Human
CAS No.	9001-30-3
Molecular Formula	Contact for details
Molecular Weight	~80,000 Da (Single chain)
Synonyms	Factor XII; Hageman Factor; F12; F XII; Plasma Thromboplastin Antecedent (PTA); Contact Factor; Coagulation Factor 12; Human Coagulation Factor XII; EC 3.4.21.38; Blood Coagulation Factor XII
EINECS	Contact for details

Quality Control

Our Coagulation Factor XII, Human is manufactured and tested under a rigorous quality management system. Each lot is characterized for identity, purity, and specific biological activity to ensure it meets the stringent requirements for diagnostic and research use. Certificates of Analysis (COA) are provided, detailing key parameters such as activity (IU/mg), purity level (by SDS-PAGE and/or HPLC), and absence of significant contaminants. We adhere to relevant industry guidelines to ensure product consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Avoid repeated freeze-thaw cycles to maintain stability and activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or frozen solution
Identification (SDS-PAGE)	Corresponds to Human Factor XII
Purity (SDS-PAGE, reduced)	≥ 90%
Specific Activity	≥ [Value] IU/mg protein
Protein Content	Determined by [Method]
Solubility	Clear, colorless solution at specified concentration
pH (in solution)	6.5 - 7.5
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.