Description

Antithrombin Iii CAS NO 9000-94-6 is a critical serine protease inhibitor and a key regulatory glycoprotein in the blood coagulation cascade. Its primary function is to inactivate thrombin and other coagulation factors, making it essential for maintaining normal hemostasis and preventing pathological thrombosis. This high-purity biological is indispensable for research, diagnostic, and therapeutic development within the pharmaceutical and biotechnology sectors.

Application

• Therapeutic Agent Development: Serves as the active pharmaceutical ingredient (API) or reference standard in the formulation of antithrombotic and anticoagulant drugs.
• Clinical Diagnostics & Assays: Used as a calibrated standard in diagnostic kits to measure antithrombin III activity or antigen levels in patient plasma for diagnosing thrombophilia.
• Biochemical & Life Science Research: Essential for in vitro studies of blood coagulation mechanisms, protein-protein interactions, and serine protease inhibition kinetics.
• Cell Culture & Biotechnology: Employed as a supplement in specific cell culture media to control protease activity and improve recombinant protein yield and stability.
• Reference Standard for QC: Acts as a primary reference material for the quality control and potency testing of plasma-derived or recombinant antithrombin III products.

Basic Information

Product Name	Antithrombin Iii
CAS No.	9000-94-6
Molecular Formula	Contact for details
Molecular Weight	~58 kDa (Glycosylated form)
Synonyms	Antithrombin III; ATIII; AT 3; Serpin C1; Heparin Cofactor; Antithrombin; Antithrombin-3; AT-III; Antithrombin III Human; Plasma Antithrombin III
EINECS	Contact for details

Quality Control

Our Antithrombin III is manufactured and tested under strict quality systems. Each batch is characterized for identity, purity, and functional activity to ensure it meets the rigorous standards required for research and development. Certificates of Analysis (COA) detailing specifications such as purity (by SDS-PAGE and HPLC), specific activity, and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or desiccant when applicable.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (IR / Electrophoresis)	Conforms to standard
Purity (SDS-PAGE)	> 95% (Reduced & Non-reduced)
Assay (Functional Activity)	> 90% of stated activity
Protein Content (Biuret / UV)	> 90% of label claim
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water or specified buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.