Description

Tyrosine o-Sulfate is a sulfated derivative of the essential amino acid L-tyrosine, characterized by the addition of a sulfate group to the phenolic hydroxyl. This specific modification is of significant interest in biochemical research and pharmaceutical development, particularly in the study of protein post-translational modifications and receptor-ligand interactions. It serves as a critical reference standard and building block for researchers and manufacturers in the life sciences sector.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of tyrosine sulfation, a key post-translational modification affecting protein-protein interactions, secretion, and receptor recognition.
• Pharmaceutical Intermediates: Acts as a specialized synthon in the development of novel peptide-based therapeutics and diagnostic agents targeting sulfated tyrosine pathways.
• Enzyme Substrate Studies: Employed as a substrate for investigating the activity and kinetics of tyrosylprotein sulfotransferase (TPST) enzymes.
• Cell Culture & Signaling Research: Utilized in cell-based assays to study the role of tyrosine sulfation in cellular signaling, inflammation, and immune response mechanisms.
• Analytical Standard: Serves as a critical calibration standard in analytical methods such as HPLC and LC-MS for the quantification of sulfated amino acids and related compounds in complex matrices.

Basic Information

Product Name	Tyrosine o-Sulfate
CAS No.	956-46-7
Molecular Formula	C9H11NO7S
Molecular Weight	277.25 g/mol
Synonyms	L-Tyrosine O-sulfate; O-Sulfo-L-tyrosine; 3-(4-Hydroxyphenyl)-2-[(sulfooxy)amino]propanoic acid; Tyrosine sulfate; Tyr(SO3H); 2-Amino-3-(4-hydroxyphenyl)propanoic acid hydrogen sulfate
EINECS	Contact for details

Quality Control

Our Tyrosine o-Sulfate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and specific tests for related substances. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.