Description

4-Amino-2,3,5,6-Tetrafluorophenol is a high-value fluorinated aromatic building block characterized by its unique combination of an amino group and multiple fluorine atoms on a phenolic core. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its fluorine atoms impart desirable properties like enhanced metabolic stability and lipophilicity. It is needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where fluorine substitution improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens in display technologies due to its polarizable structure.
• Polymer Modification: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Electronics: Building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Complex Ligand Synthesis: Utilized in preparing fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Amino-2,3,5,6-Tetrafluorophenol
CAS No.	938-63-6
Molecular Formula	C6H3F4NO
Molecular Weight	181.09 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-aminophenol; 4-Aminotetrafluorophenol; 4-Amino-2,3,5,6-tetrafluorophenol; Perfluoro-4-aminophenol; 4-Amino-2,3,5,6-tetrafluorophenol; 938-63-6; 4-Amino-2,3,5,6-tetrafluorophen-1-ol; 4-NH2-TFP
EINECS	213-350-8

Quality Control

Our 4-Amino-2,3,5,6-Tetrafluorophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent oxidation and absorption of water vapor.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.