Description

5-Oxo-L-Prolinohydrazide is a high-purity, non-proteinogenic amino acid derivative with significant utility in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of novel pharmaceuticals and bioactive molecules. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking to create peptidomimetics, enzyme inhibitors, and other complex heterocyclic structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and macrocycles to enhance stability and bioavailability in therapeutic peptides.
• Heterocyclic Chemistry: Serves as a starting material for the preparation of various nitrogen-containing heterocycles like pyrazoles and fused ring systems.
• Bioconjugation & Probe Development: Utilized in the design and synthesis of chemical probes and affinity labels for biochemical and proteomic research.
• Chiral Auxiliary & Catalyst: Its L-configuration makes it valuable as a chiral building block or ligand in asymmetric synthesis.
• Agrochemical Research: Employed in the discovery and development of new active ingredients with specific biological activities.

Basic Information

Product Name	5-Oxo-L-Prolinohydrazide
CAS No.	934-06-5
Molecular Formula	C5H9N3O2
Molecular Weight	143.15 g/mol
Synonyms	L-Pyroglutamic Acid Hydrazide; (S)-5-Oxopyrrolidine-2-carbohydrazide; 5-Oxo-L-proline hydrazide; L-Pyroglutamyl Hydrazide; (S)-Pyroglutamic Acid Hydrazide; 2-Pyrrolidone-5-carboxylic Acid Hydrazide; L-5-Oxoproline Hydrazide; L-Pyroglutamic Hydrazide
EINECS	Contact for details

Quality Control

Our 5-Oxo-L-Prolinohydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality documentation, including a detailed Certificate of Analysis (COA) for each lot, which confirms identity, purity, and impurity profiles. Our standard grade meets specifications suitable for research and commercial synthesis, with options available for GMP-compliant manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-20° to -25° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.