Description

H-D-Ala-D-Ala-D-Ala-D-Ala-Oh is a synthetic tetrapeptide composed of four consecutive D-alanine residues. This compound is a crucial building block and model substrate in advanced biochemical and pharmaceutical research, particularly in the study of enzyme mechanisms and bacterial cell wall synthesis. It serves as an essential intermediate for researchers and manufacturers in the fields of medicinal chemistry, peptide synthesis, and antibiotic development.

Application

• Biochemical Research: Used as a model substrate for studying the activity and inhibition of enzymes like D-Alanine carboxypeptidase and VanX ligase, which are involved in bacterial peptidoglycan synthesis.
• Antibiotic Development: Acts as a key intermediate in the research and synthesis of novel glycopeptide antibiotics (e.g., vancomycin analogs) that target bacterial cell wall precursors.
• Peptide Synthesis: Serves as a specialized building block for the solid-phase or solution-phase synthesis of complex peptides containing D-amino acid sequences.
• Enzyme Assays & Screening: Employed in high-throughput screening (HTS) assays to identify and characterize new antimicrobial agents or enzyme inhibitors.
• Academic & Pharmaceutical R&D: Provides a critical tool for investigating bacterial resistance mechanisms and developing new therapeutic strategies against drug-resistant pathogens.

Basic Information

Product Name	H-D-Ala-D-Ala-D-Ala-D-Ala-Oh
CAS No.	926-78-3
Molecular Formula	C12H22N4O6
Molecular Weight	318.33 g/mol
Synonyms	D-Ala-D-Ala-D-Ala-D-Ala; H-D-Ala-D-Ala-D-Ala-D-Ala-OH; Tetrapeptide (D-Ala)4; D-Alanine tetramer; (D-Ala)4; D-Ala-D-Ala-D-Ala-D-Alanine; N-(D-Alanyl)-D-alanyl-D-alanyl-D-alanine; D-Alanyl-D-alanyl-D-alanyl-D-alanine
EINECS	Contact for details

Quality Control

Our H-D-Ala-D-Ala-D-Ala-D-Ala-Oh is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through comprehensive analytical techniques including HPLC, MS, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and specific impurities is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.