Description

1-(9H-Fluoren-9-Ylmethoxycarbonylamino)-1,2,3,4-Tetrahydro-Naphthalene-1-Carboxylic Acid is a specialized Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide and peptidomimetic structures, where the Fmoc group provides orthogonal protection for the amine functionality. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of novel drug candidates and bioactive compounds. The compound, CAS 898404-95-0, is supplied with stringent quality control to ensure optimal performance in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc-strategy, used in the automated synthesis of therapeutic peptides.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the synthesis of complex, non-natural amino acids and peptidomimetics for drug discovery programs.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening against biological targets.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic Research: Employed in universities and research institutes for studying peptide structure-activity relationships and developing new synthetic methodologies.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) containing tetralin-based scaffolds.

Basic Information

Product Name	1-(9H-Fluoren-9-Ylmethoxycarbonylamino)-1,2,3,4-Tetrahydro-Naphthalene-1-Carboxylic Acid
CAS No.	898404-95-0
Molecular Formula	C26H23NO4
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-1-Amino-1,2,3,4-tetrahydro-1-naphthoic acid; Fmoc-1-Amino-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid; Fmoc-Atc-OH; Fmoc-1-Amino-1,2,3,4-tetrahydro-1-carboxynaphthalene; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-1,2,3,4-tetrahydro-1-naphthoic acid; N-Fmoc-1-amino-1,2,3,4-tetrahydro-1-naphthoic acid; 1-(Fmoc-amino)-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(9H-Fluoren-9-Ylmethoxycarbonylamino)-1,2,3,4-Tetrahydro-Naphthalene-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.