Description

4-Chloropyrimidine-2-Carbonitrile is a versatile and high-value heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, enabling critical structural modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce chloropyrimidine motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating functionalized polymers and liquid crystals.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for target identification and validation.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Nucleophilic Aromatic Substitution: The chlorine atom is readily displaced by various nucleophiles, enabling diverse derivatization.

Basic Information

Product Name	4-Chloropyrimidine-2-Carbonitrile
CAS No.	898044-48-9
Molecular Formula	C5H2ClN3
Molecular Weight	139.54 g/mol
Synonyms	2-Cyano-4-chloropyrimidine; 4-Chloro-2-pyrimidinecarbonitrile; 4-Chloro-2-cyanopyrimidine; 4-Chloropyrimidine-2-carbonitrile; 2-Pyrimidinecarbonitrile, 4-chloro-; 898044-48-9; 4-Chloro-pyrimidine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloropyrimidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.