Description

(1S-Cis)-(+/-)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol is a high-purity, advanced pharmaceutical intermediate characterized by its complex, functionalized cyclopentene and pyrimidine structure. This compound matters as a critical building block in the synthesis of novel antiviral and anticancer agents, where its stereochemistry and reactive sites enable precise molecular construction. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside analog therapeutics and other small-molecule drugs targeting viral replication and cellular proliferation pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of experimental antiviral medications.
• Anticancer Drug Development: Serves as a precursor in the synthesis of novel chemotherapeutic agents that target specific enzymatic pathways.
• Nucleoside Analog Synthesis: Used to construct modified nucleoside bases for potential use in mRNA or DNA-based therapies.
• Biochemical Research: Employed in academic and industrial labs for studying enzyme inhibition and mechanism-of-action studies.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes from laboratory to pilot and commercial scale production.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for client-specific API synthesis projects.

Basic Information

Product Name	(1S-Cis)-(+/-)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol
CAS No.	896716-96-4
Molecular Formula	C10H15ClN6O
Molecular Weight	270.72 g/mol
Synonyms	4-[(2,5-Diamino-6-chloro-4-pyrimidinyl)amino]-2-cyclopentene-1-methanol, (1S-cis)-(+-)-; 2-Cyclopentene-1-methanol, 4-[(2,5-diamino-6-chloro-4-pyrimidinyl)amino]-, (1S-cis)-(+-)-; (1S,4R)-4-((2,5-Diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol; ABT-072 Intermediate; HCV Polymerase Inhibitor Intermediate; Cyclopentenyl Pyrimidine Amine Methanol Derivative
EINECS	Contact for details

Quality Control

Our (1S-Cis)-(+/-)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.