Description

2-Methoxy-5-(Trifluoromethoxy)Phenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both methoxy and trifluoromethoxy substituents, provides valuable electronic and steric properties for designing high-performance materials and active pharmaceutical ingredients. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to incorporate trifluoromethoxy groups into target molecules to modulate bioavailability, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Polymer Chemistry: Monomer or modifier for specialty polymers, imparting unique solubility and thermal resistance properties.
• Organic Electronic Materials: Intermediate in the production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: Versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Details
Product Name	2-Methoxy-5-(Trifluoromethoxy)Phenol
CAS No.	895572-36-8
Molecular Formula	C8H7F3O3
Molecular Weight	208.14 g/mol
Synonyms	5-(Trifluoromethoxy)guaiacol; 2-Methoxy-5-(trifluoromethoxy)phenol; 1-Hydroxy-2-methoxy-4-(trifluoromethoxy)benzene; Guaiacol, 5-(trifluoromethoxy)-; Phenol, 2-methoxy-5-(trifluoromethoxy)-; 4-(Trifluoromethoxy)-2-methoxyphenol; 2-Methoxy-4-(trifluoromethoxy)phenol
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.