Description

4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylthiopyrimidine is a high-purity, synthetically valuable pyrimidine derivative, serving as a critical building block in advanced pharmaceutical research and development. Its molecular architecture, featuring a fluorophenyl group and a hydroxymethyl side chain, makes it an essential intermediate for constructing novel active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for synthesis and scale-up.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its pyrimidine core for biological activity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and enzyme inhibitors in biochemical studies.
• Material Science: Potential application as a monomer or additive in the development of specialty polymers with unique properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and novel synthetic route exploration.

Basic Information

Product Name	4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylthiopyrimidine
CAS No.	895129-11-0
Molecular Formula	C₁₆H₁₉FN₂OS
Molecular Weight	306.40 g/mol
Synonyms	5-(Hydroxymethyl)-6-isopropyl-4-(4-fluorophenyl)-2-(methylthio)pyrimidine; 4-(p-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine; 2-Methylthio-4-(4-fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidine; CAS 895129-11-0; 4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)-2-(methylsulfanyl)pyrimidine (IUPAC); 6-Isopropyl-4-(4-fluorophenyl)-5-(hydroxymethyl)-2-(methylthio)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropyl-2-Methylthiopyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.