Description

β-D-Glucopyranosiduronic Acid, 2-[[3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Oxopropyl]Amino]-4-(Hydroxymethyl)Phenyl, Methyl Ester, 2,3,4-Triacetate is a sophisticated, high-purity synthetic intermediate featuring a protected glucuronic acid moiety linked to a Fmoc-protected amino acid derivative. This compound is specifically engineered for advanced research and development in pharmaceutical chemistry, offering a critical building block for the synthesis of complex molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel drug candidates, particularly in targeted drug delivery and prodrug development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring glucuronidation for targeted release or enhanced solubility.
• Medicinal Chemistry Research: Used in the discovery and development of new chemical entities, enabling the study of structure-activity relationships (SAR) and metabolic pathways.
• Bioconjugation and Linker Chemistry: Serves as a specialized linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other targeted biotherapeutics.
• Carbohydrate Chemistry: Employed in the synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics for biological studies and therapeutic applications.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales under controlled conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	β-D-Glucopyranosiduronic Acid, 2-[[3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-1-Oxopropyl]Amino]-4-(Hydroxymethyl)Phenyl, Methyl Ester, 2,3,4-Triacetate
CAS No.	894096-02-7
Molecular Formula	C39H40N2O14
Molecular Weight	760.75 g/mol
Synonyms	Fmoc-L-2-Aminoadipic Acid β-D-Glucuronide Methyl Ester Triacetate; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pentanedioic Acid 6-[(2R,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-methoxycarbonyloxan-2-yl] 1-Methyl Ester; Fmoc-Aad(β-D-GlcA-OMe)-OH (Triacetate); Fmoc-2-Aminoadipic Acid-β-D-Glucuronide Methyl Ester Triacetate; 6-O-[(2S)-5-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-oxopentanoyl]-1,2,3,4-tetra-O-acetyl-β-D-glucopyranuronic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our β-D-Glucopyranosiduronic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.