Description

2-Chloro-n-Cyclopropyl-5-Fluoropyrimidin-4-Amine CAS NO 893772-23-1 is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated pyrimidine core. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily required by R&D laboratories and manufacturing facilities in the pharmaceutical and agrochemical sectors seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors for oncology and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its fluorinated pyrimidine structure.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds in drug discovery.
• Organic Synthesis: Employed in cross-coupling reactions and nucleophilic substitutions to introduce the cyclopropylamine moiety into target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	2-Chloro-n-Cyclopropyl-5-Fluoropyrimidin-4-Amine
CAS No.	893772-23-1
Molecular Formula	C7H7ClFN3
Molecular Weight	187.60 g/mol
Synonyms	2-Chloro-5-fluoro-N-cyclopropylpyrimidin-4-amine; 4-Amino-2-chloro-5-fluoro-N-cyclopropylpyrimidine; 2-Chloro-5-fluoropyrimidin-4-yl-cyclopropylamine; 893772-23-1; 2-Chloro-5-fluoro-N-cyclopropyl-4-pyrimidinamine; 4-Pyrimidinamine, 2-chloro-5-fluoro-N-cyclopropyl-; 2-Chloro-5-fluoro-N-cyclopropylpyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-Cyclopropyl-5-Fluoropyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.