Description

4-(5-Pyrimidinyl)Benzonitrile is a high-purity, heterocyclic aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both pyrimidine and benzonitrile moieties, makes it a versatile intermediate for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides that require specific heterocyclic scaffolds for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Chemical Biology Probes: Useful for creating labeled compounds and molecular probes for studying biological mechanisms and diagnostics.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring this specific molecular fragment.

Basic Information

Product Name	4-(5-Pyrimidinyl)Benzonitrile
CAS No.	893734-29-7
Molecular Formula	C11H7N3
Molecular Weight	181.20 g/mol
Synonyms	4-(Pyrimidin-5-yl)benzonitrile; 5-(4-Cyanophenyl)pyrimidine; Benzonitrile, 4-(5-pyrimidinyl)-; p-(5-Pyrimidinyl)benzonitrile; 4-Pyrimidin-5-yl-benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 4'-pyrimidin-5-yl- (related); 5-(4-Cyanophenyl)-1,3-diazine
EINECS	Contact for details

Quality Control

Every batch of 4-(5-Pyrimidinyl)Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profile is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.