Description

3-(4-(Trifluoromethoxy)Phenyl)Prop-2-Yn-1-Ol is a high-purity, advanced pharmaceutical intermediate featuring a trifluoromethoxy-substituted phenylacetylene core structure. This compound is valued for its role as a versatile building block in medicinal chemistry, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel active pharmaceutical ingredients (APIs), particularly in the areas of oncology, CNS disorders, and inflammation.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the trifluoromethoxy pharmacophore.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides, leveraging the stability of the CF3O group.
• Liquid Crystal & OLED Materials: A potential building block for functional materials in electronic displays due to its rigid, aromatic structure.
• Cross-Coupling Reactions: Employed in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry: An important reagent for introducing fluorine-containing motifs into target molecules, a common strategy in modern drug design.

Basic Information

Product Name	3-(4-(Trifluoromethoxy)Phenyl)Prop-2-Yn-1-Ol
CAS No.	893642-04-1
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	3-[4-(Trifluoromethoxy)phenyl]prop-2-yn-1-ol; 4-(Trifluoromethoxy)phenylacetylene methanol; 1-(4-(Trifluoromethoxy)phenyl)-2-propyn-1-ol; 2-Propyn-1-ol, 3-[4-(trifluoromethoxy)phenyl]-; 3-(4-Trifluoromethoxyphenyl)prop-2-yn-1-ol; α-Ethynyl-4-(trifluoromethoxy)benzenemethanol
EINECS	Contact for details

Quality Control

Our production of 3-(4-(Trifluoromethoxy)Phenyl)Prop-2-Yn-1-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.