Description

2-(Trifluoromethoxy)Benzyl Chloride is a versatile and high-value organofluorine building block essential for advanced chemical synthesis. Its unique structure, featuring both a reactive benzyl chloride group and a stable trifluoromethoxy substituent, makes it a critical intermediate for introducing the trifluoromethoxy pharmacophore into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and lipophilicity. The CAS number for this specific compound is 116827-40-8.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting the central nervous system, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronics: Employed in the synthesis of novel organic semiconductors and electroactive materials for OLEDs and photovoltaic cells.
• Advanced Material Science: Acts as a monomer or modifier for creating specialty polymers with unique surface properties, chemical resistance, and thermal stability.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and exploring new synthetic methodologies in academic and industrial labs.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzyl Chloride
CAS No.	116827-40-8
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	α-Chloro-2-(trifluoromethoxy)toluene; 1-(Chloromethyl)-2-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)benzyl chloride; (2-(Trifluoromethoxy)phenyl)methyl chloride; Benzene, 1-(chloromethyl)-2-(trifluoromethoxy)-; o-(Trifluoromethoxy)benzyl chloride
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Benzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.