Description

-Methyl-2-Trifluoromethylbenzyl Bromide is a high-value organobromide building block characterized by its reactive benzyl bromide group and trifluoromethyl substituent. This compound is essential for introducing the trifluoromethylbenzyl moiety into target molecules, a modification known to significantly enhance metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas like oncology, CNS disorders, and anti-infectives, where the trifluoromethyl group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the CF3 group.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel ligands for catalysis and molecular recognition applications.
• Fluorinated Compound Libraries: A crucial reagent for medicinal chemistry and discovery chemistry teams building diverse screening libraries to explore new chemical space.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	-Methyl-2-Trifluoromethylbenzyl Bromide
CAS No.	1997-80-4
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	2-(Bromomethyl)-α,α,α-trifluoro-o-xylene; 1-(Bromomethyl)-2-methyl-3-(trifluoromethyl)benzene; α-Bromo-2-methyl-α,α,α-trifluorotoluene; 2-Methyl-α,α,α-trifluorobenzyl Bromide; o-Methyl-α,α,α-trifluorobenzyl Bromide; (2-Methyl-3-(trifluoromethyl)phenyl)methyl Bromide; 3-Trifluoromethyl-2-methylbenzyl Bromide
EINECS	Contact for details

Quality Control

Our -Methyl-2-Trifluoromethylbenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and organic solvent compatibility, ensure containers are kept sealed and labeled appropriately.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.