Description

Methanol, 1,1-Difluoro-, 1-(4-Methylbenzenesulfonate) is a specialized fluorinated organic intermediate, specifically a tosylate derivative of difluoromethanol. This compound is valued for its role as a versatile building block in advanced organic synthesis, where it acts as a key reagent for introducing the difluoromethoxy group or as a protected electrophile. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of drug candidates, particularly for incorporating the metabolically stable difluoromethoxy group into bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides with enhanced properties.
• Material Science Research: Serves as a monomer or precursor in the development of specialty fluorinated polymers and advanced materials with unique surface properties.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for constructing complex molecular architectures via nucleophilic substitution reactions.
• Liquid Crystal Production: Acts as a key intermediate in the manufacture of fluorinated liquid crystal compounds for display technologies.

Basic Information

Product Name	Methanol, 1,1-Difluoro-, 1-(4-Methylbenzenesulfonate)
CAS No.	14277-20-4
Molecular Formula	C8H8F2O3S
Molecular Weight	222.21 g/mol
Synonyms	Difluoromethyl p-Toluenesulfonate; p-Toluenesulfonic Acid Difluoromethyl Ester; 4-Methylbenzenesulfonic Acid (Difluoromethyl) Ester; (Difluoromethoxy)benzene, 4-methyl-; Tosyloxy(difluoro)methane; 1,1-Difluoro-1-(tosyloxy)methane; α,α-Difluoromethyl Tosylate
EINECS	Contact for details

Quality Control

Our Methanol, 1,1-Difluoro-, 1-(4-Methylbenzenesulfonate) CAS NO 14277-20-4 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to consistent quality and traceability supports your research and scale-up processes with reliable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.