Description

2-Fluoro-6-Bromobenzyl Bromide is a versatile and highly reactive bifunctional aromatic building block, essential for constructing complex molecular architectures. Its value lies in the strategic positioning of both bromine and fluorine substituents on the benzyl scaffold, enabling selective cross-coupling and nucleophilic substitution reactions. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Used to create sophisticated phosphine or nitrogen-based ligands for transition metal catalysis in fine chemical production.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The aryl bromide moiety is ideal for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form biaryl and complex heterocyclic systems.
• Nucleophilic Substitution: The benzyl bromide group readily undergoes substitution with various nucleophiles (e.g., amines, thiols, alkoxides) to introduce functional handles.

Basic Information

Product Name	2-Fluoro-6-Bromobenzyl Bromide
CAS No.	1548-81-8
Molecular Formula	C7H5Br2F
Molecular Weight	267.92 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-6-bromobenzene; (2-Fluoro-6-bromophenyl)methyl Bromide; α-Bromo-2-fluoro-6-bromotoluene; 2-Bromo-6-(bromomethyl)fluorobenzene; 6-Bromo-2-fluorobenzyl Bromide; o-Fluoro-o'-bromobenzyl Bromide; Benzene, 1-(bromomethyl)-2-fluoro-6-bromo-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Bromobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its reactivity as a strong acid/organic solvent derivative, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.