Description

n-(5-Chlorobenzo[D][1,3]Dioxol-4-Yl)-5,7-Difluoroquinazolin-4-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound is critical for research and development in targeted therapeutic areas, offering a reliable building block for complex molecular architectures. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel small-molecule drugs, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel kinase inhibitor candidates.
• Biochemical Research: Used as a reference standard or tool compound in enzymatic and cellular assays to study biological pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Development: Employed in the synthesis of compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for chemical biology and drug discovery projects.

Basic Information

Product Name	n-(5-Chlorobenzo[D][1,3]Dioxol-4-Yl)-5,7-Difluoroquinazolin-4-Amine Hydrochloride
CAS No.	893428-68-7
Molecular Formula	C₁₅H₉ClF₂N₄O₂·HCl
Molecular Weight	383.62 g/mol (free base: 347.11 g/mol)
Synonyms	5,7-Difluoro-N-(5-chloro-1,3-benzodioxol-4-yl)quinazolin-4-amine hydrochloride; 4-Amino-5,7-difluoroquinazoline N-(5-chlorobenzo[d][1,3]dioxol-4-yl) hydrochloride; 893428-68-7 (CAS); 5-Chlorobenzo[D][1,3]Dioxol-4-Yl-5,7-Difluoroquinazolin-4-Amine HCl; 4-((5-Chloro-1,3-benzodioxol-4-yl)amino)-5,7-difluoroquinazoline hydrochloride
EINECS	Contact for details

Quality Control

Our n-(5-Chlorobenzo[D][1,3]Dioxol-4-Yl)-5,7-Difluoroquinazolin-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.