Description

1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer agents, enabling precise molecular modifications. It is primarily utilized by research institutions, custom synthesis laboratories, and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of modified nucleoside analogues for antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a building block for creating nucleoside-based chemotherapeutic agents.
• Biochemical Research: Employed in studies of enzyme kinetics, DNA/RNA synthesis inhibition, and metabolic pathways.
• Custom Synthesis: Provided to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for clinical trials.
• Process Chemistry: Used in route scouting and optimization for scalable GMP manufacturing of final APIs.

Basic Information

Product Name	1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	892223-43-7
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	5-Methyl-2'-deoxyuridine; 5-Methyldeoxyuridine; Thymidine, 2'-deoxy-; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-2'-deoxyuridine (dT); dT (when referring to the nucleoside); 5-Methyldeoxyuridine; 2'-Deoxythymidine (common misnomer, structurally related)
EINECS	Contact for details

Quality Control

Our 1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.