Description

n-[4-(4-Fluorophenyl)-6-Isopropyl-5-[(1E)-3-Oxo-1-Propenyl]-2-Pyrimidinyl]-n-Methyl-Methanesulfonamide CAS NO 890028-66-7 is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrimidine-based structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially for anti-inflammatory or kinase-inhibitor applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing complex molecules with potential anti-inflammatory or anti-cancer activity.
• Biochemical Research: Employed as a reference standard or probe compound in biochemical assays to study specific enzymatic pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	n-[4-(4-Fluorophenyl)-6-Isopropyl-5-[(1E)-3-Oxo-1-Propenyl]-2-Pyrimidinyl]-n-Methyl-Methanesulfonamide
CAS No.	890028-66-7
Molecular Formula	C20H22FN3O3S
Molecular Weight	403.47 g/mol
Synonyms	N-[4-(4-Fluorophenyl)-6-(propan-2-yl)-5-[(1E)-3-oxoprop-1-en-1-yl]pyrimidin-2-yl]-N-methylmethanesulfonamide; (E)-N-(4-(4-Fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl)-N-methylmethanesulfonamide; 890028-66-7; Methanesulfonamide, N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(1E)-3-oxo-1-propen-1-yl]-2-pyrimidinyl]-N-methyl-; A Pyrimidine Sulfonamide Derivative
EINECS	Contact for details

Quality Control

Our n-[4-(4-Fluorophenyl)-6-Isopropyl-5-[(1E)-3-Oxo-1-Propenyl]-2-Pyrimidinyl]-n-Methyl-Methanesulfonamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.