Description

5-[3,5-Bis(Trifluoromethyl)Phenyl]-3-Pyridinecarbaldehyde is a high-value, multi-functional aromatic aldehyde building block. This compound matters for its unique trifluoromethylated biphenyl-pyridine hybrid structure, which imparts significant lipophilicity, metabolic stability, and electron-withdrawing properties to final molecules. It is primarily needed by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for developing novel small molecule drugs, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging the bioactivity-enhancing trifluoromethyl groups.
• Ligand & Catalyst Development: Serves as a precursor for constructing sophisticated chelating ligands in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional organic materials.
• Chemical Biology Probes: Useful for tagging and modifying biomolecules due to its reactive aldehyde functionality.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis projects requiring fluorinated aromatic systems.

Basic Information

Product Name	5-[3,5-Bis(Trifluoromethyl)Phenyl]-3-Pyridinecarbaldehyde
CAS No.	887973-75-3
Molecular Formula	C15H7F6NO
Molecular Weight	331.21 g/mol
Synonyms	3-Pyridinecarboxaldehyde, 5-[3,5-bis(trifluoromethyl)phenyl]-; 5-(3,5-Bis(trifluoromethyl)phenyl)nicotinaldehyde; 5-[3,5-Bis(trifluoromethyl)phenyl]pyridine-3-carbaldehyde; 5-(3,5-Bis(trifluoromethyl)phenyl)-3-pyridylcarboxaldehyde; 5-(3,5-Bis(trifluoromethyl)phenyl)pyridine-3-carboxaldehyde; 887973-75-3; CAS 887973-75-3
EINECS	Contact for details

Quality Control

Our 5-[3,5-Bis(Trifluoromethyl)Phenyl]-3-Pyridinecarbaldehyde is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development from milligram to kilogram scale with full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.